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Diseases of the Eye

Macular Degeneration

What is It?
The macula is the part of the retina responsible for detailed vision and ability to see colours. Macular degeneration occurs when this area of delicate cells are irreparably damaged.

What Is The Effect On Vision?
Damage in this area disrupts the central vision. Vision may be distorted and blurry, or in severe cases lost completely.

What Are The Symptoms?
The symptoms depend on the form of the disease. There are two forms:

• Non Exudative (commonly referred to as Wet): a gradual deterioration in sharpness and some distortion
• Exudative (commonly referred to as Dry): a sudden onset of distortion of objects and waviness of straight lines

What Is The Difference Between The Two Types?
Dry: is the most common form and occurs when deposits build up on the macular area and stop the pigment cells from working. This results in a reduction in the quality of vision. The condition usually develops and progresses slowly.

Wet: is rarer, accounting for about 10% of all AMD cases. It occurs when new blood vessels grow behind the retina causing bleeding and scarring. The condition can develop very quickly.

What Causes It?
This is not yet fully understood, but it appears to be due to a breakdown in cellular metabolism.

Who Is Most At Risk?
Macular Degeneration mostly occurs in senior citizens. It is therefore commonly referred to as Age Related Macular Degeneration.

The following factors also have a bearing on its development:

Bullet Point Gender: slightly more common in women
Bullet PointFamily history : there is a genetic link
Bullet PointSmoking: increases free radical activity
Bullet PointExcessive sunlight: UV causes cell damage
Bullet PointPoor nutrition: vitamin and mineral deficiency affects photopigment cell renewal

Can It Be Tested For?
Both wet and dry forms can be picked up during a routine examination by analyzing the appearance of the macular area and performing a central visual field test. In the wet form, however it may not reveal itself at all, and can often occur very suddenly in an eye that has previously been deemed to look healthy.

More comprehensive tests such as Fluoroscein Angiograms can be done at the hospital if Wet AMD is suspected.


What Is the Treatment?
The treatment, if any, depends on the type of macular degeneration:

Exudative - Laser and drug treatment.
Non Exudative - no treatment but vision aids such as magnifiers may help

Treatment success is variable and does not usually restore lost vision. However new treatments are being developed all the time. One of the newest is PhotoDynamic Therapy (PDT) which involves a light sensitive drug being injected into the blood stream to identify abnormal blood vessels growing behind the macula. A laser shone on these vessels then activates the drug and stops the vessles form growing and causing further damage. The best results are acheived in the early stages of disease onset.

Because of the variable success rate, in some areas treatment under the NHS is not available at all, or is subject to limitations.

Further Information
More information on Macular Degeneration is available by clicking these links
:

http://www.rnib.org.uk/xpedio/groups/public/documents/PublicWebsite/public_rnib003635.hcsp
http://www.nhsdirect.nhs.uk/articles/article.aspx?articleId=399
http://www.macular-degeneration.org/
 
 
Macular Degeneration Simulation
Macular Degeneration View
 
Macular Degeneration Simulation
Normal View
 
 
 
   
   
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